xxiv, 611, G:32, I:26 pages : illustrations (some color) ; 28 cm
Includes bibliographical references and index.
1. An invitation to neurobiology. Nature and nurture in brain function and behavior ; How the nervous system organized ; General methodology ; Summary -- 2. Signaling within neurons. Cell biological and electrical properties of neurons ; How do electrical signals propagate from the neuronal cell body to its axon terminals? ; Summary -- 3. Signaling across synapses. How is neurotransmitter release controlled at the presynaptic terminal? ; How do neurotransmitters act on postsynaptic neurons? ; Summary -- 4. Vision. How do rods and cones detect light signals? ; How are signals from rods and cones analyzed in the retina? ; How is information processed in the visual cortex? ; Summary -- 5. Wiring of the visual system. How do retinal ganglion cell axons find their targets? ; How do experience and neuronal activity contribute to wiring? ; How do molecular determinants and neuronal activity work together? ; Visual system development in drosophila : linking cell fate to wiring specificity ; Summary -- 6. Olfaction, taste, audition, and somatosensation. How do we sense odors? ; How do worms and flies sense odors? ; Taste : to eat, or not to eat? ; Audition : how do we hear and localize sounds? ; Somatosensation : how do we sense body movement, touch, temperature, and pain? ; Summary -- 7. Wiring of the nervous system. How does wiring specificity arise in the developing nervous system? ; Assembly of olfactory circuits : how do neural maps form? ; How do ~20,000 genes specify 10¹⁴ connections? ; Summary -- 8. Motor and regulatory systems. How is movement controlled? ; How does the brain regulate the functions of internal organs? ; How is eating regulated? ; How are circadian rhythms and sleep regulated? ; Summary -- 9. Sexual behavior. How do genes specify sexual behavior in the fly? ; How are mammalian sexual behaviors regulated? ; Summary -- 10. Memory, learning, and synaptic plasticity. Prelude: What is memory, and how is it acquired by learning? ; How is synaptic plasticity achieved? ; What is the relationship between learning and synaptic plasticity? ; Where does learning occur, and where is memory stored in the brain? ; Summary -- 11. Brain disorders. Alzheimer's disease and other neurodegenerative diseases ; Psychiatric disorders ; Neurodevelopmental disorders ; Summary -- 12. Evolution of the nervous system. General concepts and approaches in evolutionary analysis ; Evolution of neuronal communication ; Evolution of sensory systems ; Evolution of nervous system structure and development ; Summary -- 13. Ways of exploring. Animal models in neurobiology research ; Genetic and molecular techniques ; Anatomical techniques ; Recording and manipulating neuronal activity ; Behavioral analyses ; Summary and perspectives -- Glossary.